Ultracool dwarfs consist of lowest-mass stars and brown dwarfs. Their interior is fully convective, different from that of the partly-convective Sun-like stars. Magnetic field generation process beneath the surface of ultracool dwarfs is still poorly understood and controversial. To increase samples of active ultracool dwarfs significantly, we have identified 962 ultracool dwarfs in the latest LAMOST data release, DR11. We also simulate the Chinese Space Station Survey Telescope (CSST) low-resolution slitless spectra by degrading the LAMOST spectra. A semi-supervised machine learning approach with an autoencoder model is built to identify ultracool dwarfs with the simulated CSST spectra, which demonstrates the capability of the CSST all-sky slitless spectroscopic survey on the detection of ultracool dwarfs. Magnetic activity of the ultracool dwarfs is investigated by using the H$α$ line emission as a proxy. The rotational periods of 82 ultracool dwarfs are derived based on the Kepler/K2 light curves. We also derive the activity-rotation relation of the ultracool dwarfs, which is saturated around a Rossby number of 0.12.

We present a framework for evaluating 6-DoF instance-level object pose estimators, focusing on those that require a single RGB (not RGB-D) image as input. Besides gaining intuition about how accurate these estimators are, we are interested in the degree to which they can serve as the sole perception mechanism for robotic grasping. To assess this, we perform grasping trials in a physics-based simulator, using image-based pose estimates to guide a parallel gripper and an underactuated robotic hand in picking up 3D models of objects. Our experiments on a subset of the BOP (Benchmark for 6D Object Pose Estimation) dataset compare five open-source object pose estimators and provide insights that were missing from the literature.

Accurately predicting protein fitness with minimal experimental data is a persistent challenge in protein engineering. We introduce PRIMO (PRotein In-context Mutation Oracle), a transformer-based framework that leverages in-context learning and test-time training to adapt rapidly to new proteins and assays without large task-specific datasets. By encoding sequence information, auxiliary zero-shot predictions, and sparse experimental labels from many assays as a unified token set in a pre-training masked-language modeling paradigm, PRIMO learns to prioritize promising variants through a preference-based loss function. Across diverse protein families and properties-including both substitution and indel mutations-PRIMO outperforms zero-shot and fully supervised baselines. This work underscores the power of combining large-scale pre-training with efficient test-time adaptation to tackle challenging protein design tasks where data collection is expensive and label availability is limited.

Time-dependent density functional theory (TDDFT) is a widely used method to investigate electron dynamics under external time-dependent perturbations such as laser fields. In this work, we present a machine learning approach to accelerate electron dynamics simulations based on real time TDDFT using autoregressive neural operators as time-propagators for the electron density. By leveraging physics-informed constraints and featurization, and high-resolution training data, our model achieves superior accuracy and computational speed compared to traditional numerical solvers. We demonstrate the effectiveness of our model on a class of one-dimensional diatomic molecules under the influence of a range of laser parameters. This method has potential in enabling on-the-fly modeling of laser-irradiated molecules and materials by utilizing fast machine learning predictions in a large space of varying experimental parameters of the laser.

Existing curved-layer-based process planning methods for multi-axis manufacturing address collisions only indirectly and generate toolpaths in a post-processing step, leaving toolpath geometry uncontrolled during optimization. We present an implicit neural field-based framework for multi-axis process planning that overcomes these limitations by embedding both layer generation and toolpath design within a single differentiable pipeline. Using sinusoidally activated neural networks to represent layers and toolpaths as implicit fields, our method enables direct evaluation of field values and derivatives at any spatial point, thereby allowing explicit collision avoidance and joint optimization of manufacturing layers and toolpaths. We further investigate how network hyperparameters and objective definitions influence singularity behavior and topology transitions, offering built-in mechanisms for regularization and stability control. The proposed approach is demonstrated on examples in both additive and subtractive manufacturing, validating its generality and effectiveness.

Open-weight bio-foundation models present a dual-use dilemma. While holding great promise for accelerating scientific research and drug development, they could also enable bad actors to develop more deadly bioweapons. To mitigate the risk posed by these models, current approaches focus on filtering biohazardous data during pre-training. However, the effectiveness of such an approach remains unclear, particularly against determined actors who might fine-tune these models for malicious use. To address this gap, we propose BioRiskEval, a framework to evaluate the robustness of procedures that are intended to reduce the dual-use capabilities of bio-foundation models. BioRiskEval assesses models' virus understanding through three lenses, including sequence modeling, mutational effects prediction, and virulence prediction. Our results show that current filtering practices may not be particularly effective: Excluded knowledge can be rapidly recovered in some cases via fine-tuning, and exhibits broader generalizability in sequence modeling. Furthermore, dual-use signals may already reside in the pretrained representations, and can be elicited via simple linear probing. These findings highlight the challenges of data filtering as a standalone procedure, underscoring the need for further research into robust safety and security strategies for open-weight bio-foundation models.

Data-driven methods for electrocardiogram (ECG) interpretation are rapidly progressing. Large datasets have enabled advances in artificial intelligence (AI) based ECG analysis, yet limitations in annotation quality, size, and scope remain major challenges. Here we present CODE-II, a large-scale real-world dataset of 2,735,269 12-lead ECGs from 2,093,807 adult patients collected by the Telehealth Network of Minas Gerais (TNMG), Brazil. Each exam was annotated using standardized diagnostic criteria and reviewed by cardiologists. A defining feature of CODE-II is a set of 66 clinically meaningful diagnostic classes, developed with cardiologist input and routinely used in telehealth practice. We additionally provide an open available subset: CODE-II-open, a public subset of 15,000 patients, and the CODE-II-test, a non-overlapping set of 8,475 exams reviewed by multiple cardiologists for blinded evaluation. A neural network pre-trained on CODE-II achieved superior transfer performance on external benchmarks (PTB-XL and CPSC 2018) and outperformed alternatives trained on larger datasets.

Designing protein sequences of both high fitness and novelty is a challenging task in data-efficient protein engineering. Exploration beyond wild-type neighborhoods often leads to biologically implausible sequences or relies on surrogate models that lose fidelity in novel regions. Here, we propose ProSpero, an active learning framework in which a frozen pre-trained generative model is guided by a surrogate updated from oracle feedback. By integrating fitness-relevant residue selection with biologically-constrained Sequential Monte Carlo sampling, our approach enables exploration beyond wild-type neighborhoods while preserving biological plausibility. We show that our framework remains effective even when the surrogate is misspecified. ProSpero consistently outperforms or matches existing methods across diverse protein engineering tasks, retrieving sequences of both high fitness and novelty.

Abstract-- Robust 6D pose estimation of novel objects under challenging illumination remains a significant challenge, often requiring a trade-off between accurate initial pose estimation and efficient real-time tracking. We present a unified framework explicitly designed for efficient execution on edge devices, which synergizes a robust initial estimation module with a fast motion-based tracker . The key to our approach is a shared, lighting-invariant color-pair feature representation that forms a consistent foundation for both stages. For initial estimation, this feature facilitates robust registration between the live RGB-D view and the object's 3D mesh. Extensive experiments on benchmark datasets demonstrate that our integrated approach is both effective and robust, providing competitive pose estimation accuracy while maintaining high-fidelity tracking even through abrupt pose changes. Estimation of an object's six-degree-of-freedom (6D) pose, which involves determining its 3D rotation and 3D translation relative to a camera, is a fundamental task in computer vision and robotics [1]. Accurate 6D pose information is crucial for a variety of applications, ranging from robotic manipulation and grasping in industrial and household environments to immersive experiences in augmented and mixed reality. The ability of an autonomous system to precisely locate and determine the orientation of objects is a key prerequisite for meaningful physical interaction. Furthermore, in dynamic scenarios, this capability must extend beyond single-frame estimation to continuous, real-time tracking, providing the temporal coherence necessary for tasks such as closed-loop robotic control. Historically, pose estimation has focused on instance-level methods, which require costly, object-specific training and thus cannot generalize to new objects. While category-level approaches can handle unseen instances within a known class, they still fail to address entirely novel categories.

End-to-end robot manipulation policies offer significant potential for enabling embodied agents to understand and interact with the world. Unlike traditional modular pipelines, end-to-end learning mitigates key limitations such as information loss between modules and feature misalignment caused by isolated optimization targets. Despite these advantages, existing end-to-end neural networks for robotic manipulation--including those based on large VLM/VLA models--remain insufficiently performant for large-scale practical deployment. In this paper, we take a step towards an end-to-end manipulation policy that is generalizable, accurate and reliable. To achieve this goal, we propose a novel Chain of Moving Oriented Keypoints (CoMOK) formulation for robotic manipulation. Our formulation is used as the action representation of a neural policy, which can be trained in an end-to-end fashion. Such an action representation is general, as it extends the standard end-effector pose action representation and supports a diverse set of manipulation tasks in a unified manner. The oriented keypoint in our method enables natural generalization to objects with different shapes and sizes, while achieving sub-centimeter accuracy. Moreover, our formulation can easily handle multi-stage tasks, multi-modal robot behaviors, and deformable objects. Extensive simulated and hardware experiments demonstrate the effectiveness of our method.